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Pregled bibliografske jedinice broj: 599027

Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center


Nemet, Damir; Ostojić, Alen; Dreta, Barbara; Lučev, Nikolina; Sertić, Dubravka; Radman, Ivo; Bojanić, Ines; Batinić, Drago; Serventi-Seiwerth, Ranka; Bašić-Kinda, Sandra et al.
Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center // ABSTRACT BOOK - HAEMATOLOGICA, 2012 ; 97(s1) / Jan Cools (ur.).
Pavia, Italija: Ferrata-Storti Foundation/European Hematology Association, 2012. str. 602-602 (ostalo, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 599027 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center

Autori
Nemet, Damir ; Ostojić, Alen ; Dreta, Barbara ; Lučev, Nikolina ; Sertić, Dubravka ; Radman, Ivo ; Bojanić, Ines ; Batinić, Drago ; Serventi-Seiwerth, Ranka ; Bašić-Kinda, Sandra ; Aurer, Igor ; Duraković, Nadira ; Zupančić- Šalek, Silva ; Mikulić, Mirta ; Rončević, Pavle ; Pulanić, Dražen ; Boban, Ana ; Kovačević- Metelko, Jasminka ; Labar, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ABSTRACT BOOK - HAEMATOLOGICA, 2012 ; 97(s1) / Jan Cools - Pavia, Italija : Ferrata-Storti Foundation/European Hematology Association, 2012, 602-602

Skup
17TH CONGRESS OF THE EUROPEAN HEMATOLOGY ASSOCIATION

Mjesto i datum
Amsterdam, Nizozemska, 14.-17.06.2012

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Multiple myeloma ; Treatment ; Survival

Sažetak
BACKGROUND: Therapy of multiple myeloma (MM) has been greatly advanced by introduction of autologous hematopoietic stem cell transplantation (AHSCT) in 90’s, and appearance of new potent drugs thalidomide, bortezomib and lenalidomide in the last decade. AIMS: to assess the efficacy of new treatment modalities on survival of MM patients treated at the University Hospital Center, Zagreb. PATIENTS AND METHODS: From 1985 till 2010, 560 consecutive MM patients (pts) were analyzed. Median age at diagnosis was 60 (range 28-89) years. Pts were divided into three groups according to time period of available treatment modalities: Group one treated from 1985-1995, period prior AHSCT (n=158, median age 63 [range: 31-87]) ; group two treated from 1996- 2001, period with AHSCT (n=139, median age 58 [range: 29-87]) ; and group three treated from 2002-2010, period with AHSCT+bortezomib+thalidomide (n=263, median age 60 [range: 28-89]). Each group was subdivided in two subgroups according to age at diagnosis indicating eligibility for AHSCT (<65 and ≥65 years of age). Estimated median overall survival (OS) was calculated by Kaplan-Meier method. Differences between groups were tested by 2-tailed log-rank test with p value of <.05 being statistically significant. RESULTS: Median follow-up for entire cohort was 42.5 (range: 1-267 months). Seventy-three pts were lost from follow-up after median time of 16 (range: 1-123) months. Estimated median OS was 69 (95%CI 59.07-78.93) months. For groups 1 and 2, estimated median OS were 38 (95%CI 29.44- 46.56) and 47 (95%CI 36.06-57.94) months respectively, while for the group 3 estimated median OS was not reached for the median follow-up of 48 (range: 1-118) months. OS was significantly different between all groups: groups 1:2 (p=0.009), groups 2:3 (p<0.0001), groups 1:3 (p<0.0001) (Fig. 1). When adjusted for age, significance between groups 1 and 2 was not reached (p=0.058) although showing trends for better OS in group 2. Statistically significant difference remained between groups 1:3 and 2:3 (p<0.0001, for each). OS for patients younger than 65 are significantly better compared to patients with 65 years or older, in all three groups. CONCLUSIONS: The analysis of OS clearly showed significantly better outcome for pts treated with AHSCT, especially for younger patients. In most recent time period both younger and older patients showed better OS probably due to introduction of new treatment modalities with thalidomide or bortezomib. Results of the study are in accordance with other similar retrospective analyses.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1081872-2061 - LIMFOPROLIFERATIVNE BOLESTI I TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA (Nemet, Damir, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Sveučilište Libertas

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Nemet, Damir; Ostojić, Alen; Dreta, Barbara; Lučev, Nikolina; Sertić, Dubravka; Radman, Ivo; Bojanić, Ines; Batinić, Drago; Serventi-Seiwerth, Ranka; Bašić-Kinda, Sandra et al.
Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center // ABSTRACT BOOK - HAEMATOLOGICA, 2012 ; 97(s1) / Jan Cools (ur.).
Pavia, Italija: Ferrata-Storti Foundation/European Hematology Association, 2012. str. 602-602 (ostalo, međunarodna recenzija, sažetak, znanstveni)
Nemet, D., Ostojić, A., Dreta, B., Lučev, N., Sertić, D., Radman, I., Bojanić, I., Batinić, D., Serventi-Seiwerth, R. & Bašić-Kinda, S. (2012) Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center. U: Jan Cools (ur.)ABSTRACT BOOK - HAEMATOLOGICA, 2012 ; 97(s1).
@article{article, author = {Nemet, Damir and Ostoji\'{c}, Alen and Dreta, Barbara and Lu\v{c}ev, Nikolina and Serti\'{c}, Dubravka and Radman, Ivo and Bojani\'{c}, Ines and Batini\'{c}, Drago and Serventi-Seiwerth, Ranka and Ba\v{s}i\'{c}-Kinda, Sandra and Aurer, Igor and Durakovi\'{c}, Nadira and Zupan\v{c}i\'{c}- \v{S}alek, Silva and Mikuli\'{c}, Mirta and Ron\v{c}evi\'{c}, Pavle and Pulani\'{c}, Dra\v{z}en and Boban, Ana and Kova\v{c}evi\'{c}- Metelko, Jasminka and Labar, Boris}, year = {2012}, pages = {602-602}, keywords = {Multiple myeloma, Treatment, Survival}, title = {Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center}, keyword = {Multiple myeloma, Treatment, Survival}, publisher = {Ferrata-Storti Foundation/European Hematology Association}, publisherplace = {Amsterdam, Nizozemska} }
@article{article, author = {Nemet, Damir and Ostoji\'{c}, Alen and Dreta, Barbara and Lu\v{c}ev, Nikolina and Serti\'{c}, Dubravka and Radman, Ivo and Bojani\'{c}, Ines and Batini\'{c}, Drago and Serventi-Seiwerth, Ranka and Ba\v{s}i\'{c}-Kinda, Sandra and Aurer, Igor and Durakovi\'{c}, Nadira and Zupan\v{c}i\'{c}- \v{S}alek, Silva and Mikuli\'{c}, Mirta and Ron\v{c}evi\'{c}, Pavle and Pulani\'{c}, Dra\v{z}en and Boban, Ana and Kova\v{c}evi\'{c}- Metelko, Jasminka and Labar, Boris}, year = {2012}, pages = {602-602}, keywords = {Multiple myeloma, Treatment, Survival}, title = {Advances in the treatment of multiple myeloma: survival analysis of 560 patients in a twenty- five years period in a single center}, keyword = {Multiple myeloma, Treatment, Survival}, publisher = {Ferrata-Storti Foundation/European Hematology Association}, publisherplace = {Amsterdam, Nizozemska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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