engleski

Ultrasound imaging of structural recovery after perinatal brain damage

103 infants with ultrasound appearance of increased echogenicity (leukomalacia or haemorrhage) were followed up during the 20 months period to reveal structural recovery and the differences in the structural recovery between the younger (YG less than 34 weeks gestation, 61 infant) and older group (OG more than 34 weeks gestation, 42 infants). Echolucent cavities developed in 16 infants in YG in three weeks and in 14 infants in OG in four weeks. In the YG cavities were more often multiple (in ten) and bilateral (in nine) in contrast to the OG in which cavities were solitary and unilateral (in eleven). In twelve infants in YG cavities disappeared in 16 weeks and in OG in 26 weeks. Final ultrasound finding after unilateral cavities was normal in four out of six infants in YG and only in two out of 11 in OG. In both groups the outcome after multiple cavities was unfavourable. Faster and better structural recovery after solitary and unilateral cavities in YG could be explained by the fact that the lesion occured during the developmental peak of the "subplate" zone with the transient population of waiting axons and cells which may participate in the structurtal plasticity after perinatal brain damage. Multiple lesions have poor outcome in both groups because they destroy this capacity for recovery.

nije evidentirano

nije evidentirano