Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Clenbuterol and salbutamol blood concentrations in treated animals (CROSBI ID 590666)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Pleadin, Jelka ; Durgo, Ksenija ; Vulić, Ana ; Perši, Nina ; Terzić, Svjetlana ; Mihaljević, Željko Clenbuterol and salbutamol blood concentrations in treated animals // Arhiv za higijenu rada i toksikologiju / Želježić, Davor (ur.). 2012. str. 64-64

Podaci o odgovornosti

Pleadin, Jelka ; Durgo, Ksenija ; Vulić, Ana ; Perši, Nina ; Terzić, Svjetlana ; Mihaljević, Željko

engleski

Clenbuterol and salbutamol blood concentrations in treated animals

The β-adrenergic agonist clenbuterol and salbutamol are pharmacologically active substances with anabolic effects, which bind to the specifi c β-adrenergic receptors found on cell membranes of the animal target tissues. The use of these substances as growth promoters for fattening purposes has been banned in the European Union. The aim of the present study was to determine clenbuterol and salbutamol blood concentrations, separately in the plasma and serum of animals after their exposure. The experimental group of guinea pigs (n=20) were treated with two dosages (0.25 mg kg-1 and 2.5 mg kg-1) of clenbuterol (n=10) and salbutamol (n=10) for 7 days, respectively, whereas the control group of animals (n=10) were left completely untreated. Validation of applied ELISA method showed acceptable recovery (R>70 %) and repeatability (CV<10 %) for all serum and plasma samples to which clenbuterol and salbutamol were added. This has proven the method to be applicable for quantitative determination of both analytes and matrices, preferably in plasma. Study results pointed to signifi cantly higher (about 14-fold) clenbuterol concentrations (1287±293) μg L-1 in comparison to salbutamol (95±20) μg L-1 in plasma, and generally higher concentrations of both analytes in plasma than in serum. Application of higher exposure dose resulted in about four-fold and three-fold higher clenbuterol and salbutamol concentrations, respectively, and pointed to a different rate of release of these two β-agonists.

β-adrenergic agonist; clenbuterol; ELISA; guinea pigs; plasma; serum; salbutamol

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

64-64.

2012.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Arhiv za higijenu rada i toksikologiju

Želježić, Davor

Zagreb: Hrvatsko toksikološko društvo

0004-1254

Podaci o skupu

CROTOX

poster

02.10.2012-05.10.2012

Primošten, Hrvatska

Povezanost rada

Veterinarska medicina, Biotehnologija, Prehrambena tehnologija

Poveznice
Indeksiranost