Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 597923

Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report


Lasan Trčić, Ružica; Kardum-Skelin, Ika; Šiftar, Zoran; Šentija, Karmela; Vrhovac, Radovan; Jakšić, Branimir; Ostojić Kolonić, Slobodanka; Begović, Davor.
Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report // Cytopathology Volume 23 Supplement 1 / Herbert, A ; Cochand-Priollet, B (ur.).
Oxford, UK: Blackwell Publishing Ltd, 2012. str. 81-81 (poster, međunarodna recenzija, sažetak, stručni)


CROSBI ID: 597923 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report

Autori
Lasan Trčić, Ružica ; Kardum-Skelin, Ika ; Šiftar, Zoran ; Šentija, Karmela ; Vrhovac, Radovan ; Jakšić, Branimir ; Ostojić Kolonić, Slobodanka ; Begović, Davor.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Cytopathology Volume 23 Supplement 1 / Herbert, A ; Cochand-Priollet, B - Oxford, UK : Blackwell Publishing Ltd, 2012, 81-81

Skup
37th European Congress of Cytology

Mjesto i datum
Dubrovnik-Cavtat, Hrvatska, 30.9.-3.10. 2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acute myeloid leukemia; t(6; 9)(p23; q34)

Sažetak
Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML) (about 1% of all AML), and correlates with poor clinical outcome. Most patients with this disease are diagnosed with AML according to the FAB classification of M2 or M4, and many show evidence of underlying or preceding myelodysplasia. Methods: Diagnostic bone marrow samples were diagnosed by morphological, immunophenotypical criteria, and reverse transcriptase polymerase chain reaction. Chromosome studies were performed on GTG-banded chromosomes obtained from bone marrow after direct preparation or short-time cultures (24 hour). At least 20 methaphases for each sample were analyzed. FISH studies were done using BCR/ABL1 dual-color/dual_fusion probes (Kreatech, Vysys), 200 interphase nuclei (I-FISH) and on all available methaphases were analysed. Karyotypes and FISH results were described to ISCN (2009). Results: Here we describe a case of AML with t(6 ; 9)(p23 ; q34). A 69-year old male was diagnosed as having AML-M4 based on morphology, cytochemistry and immunophenotype. The blast cells were positive for CD45, CD33, CD13, CD117, CD34, MPO, and negative for CD14, CD4, CD61 and CD235a AML. Cytogenetic analysis of bone marrow showed in all metaphase cells bearing t(6 ; 9) as solitary abnormality in the 20 metaphase cells examened. There was poor response to chemotherapy in that patient, he developed severe sepsis and died in 5 months. Conclusion: It is well recognized that the t(6 ; 9) defines a subgroup of AML with poor outcome. It has been included as a separate entity in the revised 2008 World Health Organization classification of AML.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081873-1893 - Prognostički faktori, dijagnostika i terapija hemoblastoza (Branimir Jakšić, )
198-1980955-0953 - Imunobiologija kronične B-limfocitne leukemije i mikrookoliš (Ozren Jakšić, )
108-0000000-3455 - Dijagnostika i terapija infekcija kod imunokompromitiranih bolesnika (Radovan Vrhovac, )

Ustanove
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Akademija medicinskih znanosti

Citiraj ovu publikaciju

Lasan Trčić, Ružica; Kardum-Skelin, Ika; Šiftar, Zoran; Šentija, Karmela; Vrhovac, Radovan; Jakšić, Branimir; Ostojić Kolonić, Slobodanka; Begović, Davor.
Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report // Cytopathology Volume 23 Supplement 1 / Herbert, A ; Cochand-Priollet, B (ur.).
Oxford, UK: Blackwell Publishing Ltd, 2012. str. 81-81 (poster, međunarodna recenzija, sažetak, stručni)
Lasan Trčić, R., Kardum-Skelin, I., Šiftar, Z., Šentija, K., Vrhovac, R., Jakšić, B., Ostojić Kolonić, S. & Begović, D. (2012) Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report. U: Herbert, A. & Cochand-Priollet, B. (ur.)Cytopathology Volume 23 Supplement 1.
@article{article, year = {2012}, pages = {81-81}, keywords = {acute myeloid leukemia, t(6, 9)(p23, q34)}, title = {Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report}, keyword = {acute myeloid leukemia, t(6, 9)(p23, q34)}, publisher = {Blackwell Publishing Ltd}, publisherplace = {Dubrovnik-Cavtat, Hrvatska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font