engleski

Gene expression levels of different drug transporters in human NSCLC cell lines

Drug transporters are membrane proteins involved in all aspects of drug up-take and function. As such they are potential therapeutic targets. In recent years an enormous progress has been made in understanding the role of drug transporters in kidney, intestine, liver and brain. In contrast, little is known about the role of drug transporters in the lung. Even less is known about drug transporters in pulmonary diseases and their potential role in developing resistance to therapy. Our first results have been gained with qPCR from 2D cell cultures of lung adenocarcinoma (A549 and H2122) and squamous cell lung carcinoma (H157 and H520) cell lines. A marked decrease of Organic Cation Transporter SLC22A3 gene expression in squamous cell carcionoma and of Organic Anion Transporter Polypeptide SLCO4C1 gene expression in adenocarcinoma have been detected. Further experiments are on their way to confirm the above data in primary tumour samples and investigate the functional role of the above transporters in lung epithelium

drug transporters; NSCLC; resistance to therapy

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