engleski

Antioxidant activity of some (7-hydroxy-2-oxo-2H- chromen-4-yl)acetic acid derivatives

A series of coumarin Schiff bases (7- (arylidenehydrazinocarbonylmethoxy)-2-oxo-2H- chromen-4-yl]acetic acid arylidenehydrazide) (4a- k) and N-(2-aryl-4-oxothiazolidin-3-yl)-2-{; ; [4-(2- aryl-4-oxothiazolidin-3-yl)carbamoylmethyl]-2-oxo- 2H-chromen-7-yloxy}; ; -acetamides (5a-k) were synthesized and evaluated for their antioxidant activity (scavenging of 1, 1-diphenyl-2- picryhydrazyl radical and phosphomolybdenum method). Compounds with 3, 4-dihydroxyphenyl and 2, 5-dihidroxyphenyl ring showed the best 1, 1- diphenyl-2-picryhydrazyl (DPPH) scavenging activity, whereas the best activity investigated by phosphomolybdenum method was found for the compounds with 2, 5-hihidroxydiphenyl ring.

coumarin ; antioxidant activity ; Schiff base ; 4-thiazolidinone

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