engleski

Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives

In research for antiviral and antitumor substances, many derivatives of natural nucleosides have been synthesized and used in treatment of viral, tumor and bacterial diseases. Numerous synthesized 3-deazapurine derivatives have shown signifficant biologial activity on the wide range of RNA and DNA viruses, broad leukemia tumor cells lines and as antituberculostatics. In light of these findings and based on our previous study, we efficiently synthesized a series of new derivatives of halogenated 3-deazapurines (A, B) and L-ascorbic (1-4, 7-8) or imino-L-ascorbic acid (5-6) as a substitute for sugar moiety to evaluate their antiviral and antitumor potency.

halogenirani 3-deazapurini; L-askorbinska kiselina

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