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Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives


Stipković Babić, Maja; Mintas, Mladen
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives // ISMC 2012, XXIInd International Symposium on Medicinal Chemistry / Ortúzar, Natalia (ur.).
Berlin: WILEY-VCH Verlag GmbH& Co. KGaA, 2012. str. 378-378 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives

Autori
Stipković Babić, Maja ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ISMC 2012, XXIInd International Symposium on Medicinal Chemistry / Ortúzar, Natalia - Berlin : WILEY-VCH Verlag GmbH& Co. KGaA, 2012, 378-378

Skup
ISMC 2012, XXIInd International Symposium on Medicinal Chemistry

Mjesto i datum
Berlin, Njemačka, 2.-6.9.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
halogenated 3-deazapurine; L-ascorbic acid
(halogenirani 3-deazapurini; L-askorbinska kiselina)

Sažetak
In research for antiviral and antitumor substances, many derivatives of natural nucleosides have been synthesized and used in treatment of viral, tumor and bacterial diseases. Numerous synthesized 3-deazapurine derivatives have shown signifficant biologial activity on the wide range of RNA and DNA viruses, broad leukemia tumor cells lines and as antituberculostatics. In light of these findings and based on our previous study, we efficiently synthesized a series of new derivatives of halogenated 3-deazapurines (A, B) and L-ascorbic (1-4, 7-8) or imino-L-ascorbic acid (5-6) as a substitute for sugar moiety to evaluate their antiviral and antitumor potency.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Mladen Mintas (autor)

Avatar Url Maja Stipković Babić (autor)

Citiraj ovu publikaciju

Stipković Babić, Maja; Mintas, Mladen
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives // ISMC 2012, XXIInd International Symposium on Medicinal Chemistry / Ortúzar, Natalia (ur.).
Berlin: WILEY-VCH Verlag GmbH& Co. KGaA, 2012. str. 378-378 (poster, međunarodna recenzija, sažetak, znanstveni)
Stipković Babić, M. & Mintas, M. (2012) Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives. U: Ortúzar, N. (ur.)ISMC 2012, XXIInd International Symposium on Medicinal Chemistry.
@article{article, editor = {Ort\'{u}zar, N.}, year = {2012}, pages = {378-378}, keywords = {halogenirani 3-deazapurini, L-askorbinska kiselina}, title = {Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives}, keyword = {halogenirani 3-deazapurini, L-askorbinska kiselina}, publisher = {WILEY-VCH Verlag GmbH and Co. KGaA}, publisherplace = {Berlin, Njema\v{c}ka} }