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Synthesis of Novel Ureido and Hydroxamic Derivatives of Coumarin[4, 3-c]thiophene

Aromatic urea derivatives have been widely used for cancer patients with great clinical success and are continuing to be important chemotherapeutic agents. This class of compounds has been proven to be tubulin ligands that inhibit the polymerization of tubulin. We synthesized a series of novel ureido (6b–10b) and hydroxamic (12b– 13b) derivatives of coumarin[4, 3-c]thiophene for their antitumor and antiviral activity evaluation.

Ureido and Hydroxamic Derivatives of Coumarin[4; 3-c]thiophene

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