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Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity


Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity // XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia (ur.).
Berlin: WILEY-VCH Verlag GmbH& Co. KGaA, 2012. str. 379-379 (poster, sažetak, znanstveni)


Naslov
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity

Autori
Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia - Berlin : WILEY-VCH Verlag GmbH& Co. KGaA, 2012, 379-379

Skup
International Symposium on Medicinal Chemistry (22 ; 2012)

Mjesto i datum
Berlin, Njemačka, 02-06.09.2012.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Neobjavljeni rad

Ključne riječi
Coumarin derivatives containing 1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine moiety; cytostatic activity

Sažetak
Here, we report the synthesis and in vitro antitumor effects of a series of novel 1, 2, 4-triazole (3–6), 4, 5-dicyanoimidazole (7), and purine (8–13) coumarin derivatives and their acyclic nucleoside analogues (14–18). The structures of novel compounds 3–18 were deduced from their 1H and 13C NMR data and corresponding mass spectra. Results of an antiproliferative assay performed on a panel of selected human tumor cell lines revealed that compound 6 has moderate cytostatic activity against the HeLa cell line (IC50=35 μm), whereas compound 10 shows moderate activity against HeLa (IC50=33 μm), HepG2 (IC50=25 μm) and SW620 (IC50=35 μm) cell lines. These compounds exhibited no cytotoxic effect on normal (diploid) human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-239

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE