Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines (CROSBI ID 186459)
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Podaci o odgovornosti
Gazivoda Kraljević, Tatjana ; Bistrović, Andrea ; Dedić, Matea ; Kraljević Pavelić, Sandra ; Sedić, Mirela ; Raić-Malić, Silvana
engleski
Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines
A series of the novel 5-alkynyl- and furo[2, 3-d]pyrimidine derivatives in which the sugar moiety is replaced by a methoxymethyl (MOM) group is synthesised using the Sonogashira cross-coupling reaction under both conventional and microwave conditions, in good to excellent yields. The 5-endo-dig cyclisation of 5-alkynylpyrimidine derivatives promoted by a Pd-catalyst or base gives the corresponding furo[2, 3-d]pyrimidines in good yields.
5-alkynylpyrimidines ; furo[2, 3-d]pyrimidines ; N-methoxymethylated pyrimidine derivatives ; Sonogashira cross-coupling reaction ; 5-endo-dig cyclisation
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Podaci o izdanju
53 (38)
2012.
5144-5147
objavljeno
0040-4039
1873-3581
10.1016/j.tetlet.2012.07.068