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The effect of Mediterranean-style and Standard Hypolipemic Diet on lipid profile in obese patients: a 6-month Randomized Controlled Trial- Preliminary Results

INTRODUCTION Nowdays, numerous evidence are showing beneficial effects of Mediterranean diet on cardiovascular disease and its components. However, there are still some ambiguities and a need for more randomized studies with stronger evidence is needed. Our aim was to explore the effect of Mediterranean diet on lipid profile in obese patients in a randomized controlled study. METHODOLOGY Sixty- three subjects with a body mass index (BMI) above 30 kg/m2 were recruited from the outpatient Clinic of Department of endocrinology, diabetes and metabolism disorders at the Dubrava University Hospital in the period from November 2008 to June 2010, and were randomly assigned to either a Mediterranean diet (MD) or Standard hypolipemic diet (SHD). All subjects received education on their diet during one-week stay in Daily hospital. To determine the lipid profiles their blood samples were obtained from the antecubital vein at baseline and after 7 days, 1, 3, and 6 months. Obtained data were entered into SPSS version 14.0 (SPSS Inc, Chicago, III) and analyzed. RESULTS AND DISCUSSION The significant increase in the HDL cholesterol value of 20.3% (P=0.015) was induced by the MD group, whereas decrease of 2.17% (P=0.698) was observed by the SHD group. In the MD group we also observed decrease in the triglyceride values, however non-significant. Cholesterol showed a tendency of declining throughout the first 3-month period ; however, on the last visit a discrete, unexpected increase was noted. LDL demonstrated similar behaviour ; increasing and decreasing throughout the whole 6-month period. CONCLUSIONS MD showed higher beneficial influence on HDL colesterol than SHD what supported previous study results. Positive effect on other lipid profile markers was noticed only in the first three months, while their subsequent tendency to increase should be further explored.

mediterranean diet; standard hypolipemic diet; lipid profile

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