Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity (CROSBI ID 186231)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity // Molecules, 17 (2012), 9; 11010-11025. doi: 10.3390/molecules170911010

Podaci o odgovornosti

Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen

engleski

Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity

We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1, 2, 4-triazole (compounds 3–6), 4, 5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.

1 ; 2 ; 4-triazole ; 4 ; 5-dicyanoimidazole and purine coumarin derivatives ; acyclic nucleoside analogues ; antitumor activity evaluation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

17 (9)

2012.

11010-11025

objavljeno

1420-3049

10.3390/molecules170911010

Povezanost rada

Kemija

Poveznice
Indeksiranost