Naslov
Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity

Autori
Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen

Izvornik
Molecules (1420-3049) 17 (2012), 9; 11010-11025

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1 ; 2 ; 4-triazole ; 4 ; 5-dicyanoimidazole and purine coumarin derivatives ; acyclic nucleoside analogues ; antitumor activity evaluation

Sažetak
We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1, 2, 4-triazole (compounds 3–6), 4, 5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA