Pregled bibliografske jedinice broj: 592759
Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity
Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity // Molecules, 17 (2012), 9; 11010-11025 doi:10.3390/molecules170911010 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 592759 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Novel coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity
Autori
Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen
Izvornik
Molecules (1420-3049) 17
(2012), 9;
11010-11025
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
1 ; 2 ; 4-triazole ; 4 ; 5-dicyanoimidazole and purine coumarin derivatives ; acyclic nucleoside analogues ; antitumor activity evaluation
Sažetak
We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1, 2, 4-triazole (compounds 3–6), 4, 5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
335-0982464-239
MZOS-125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju
Profili:
Mirela Sedić
(autor)
Mladen Mintas
(autor)
Sandra Kraljević Pavelić
(autor)
Leo Mandić
(autor)
Krešimir Pavelić
(autor)
Krešimir Benci
(autor)
Marko Klobučar
(autor)
Karlo Wittine
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE