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Pregled bibliografske jedinice broj: 592759

Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity


Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity // Molecules, 17 (2012), 9; 11010-11025 doi:10.3390/molecules170911010 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 592759 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity

Autori
Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen

Izvornik
Molecules (1420-3049) 17 (2012), 9; 11010-11025

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine coumarin derivatives; acyclic nucleoside analogues; antitumor activity evaluation

Sažetak
We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1, 2, 4-triazole (compounds 3–6), 4, 5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
335-0982464-239
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( POIROT)
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( POIROT)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Citiraj ovu publikaciju

Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity // Molecules, 17 (2012), 9; 11010-11025 doi:10.3390/molecules170911010 (međunarodna recenzija, članak, znanstveni)
Benci, K., Mandić, L., Suhina, T., Sedić, M., Klobučar, M., Kraljević Pavelić, S., Pavelić, K., Wittine, K. & Mintas, M. (2012) Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity. Molecules, 17 (9), 11010-11025 doi:10.3390/molecules170911010.
@article{article, year = {2012}, pages = {11010-11025}, DOI = {10.3390/molecules170911010}, keywords = {1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine coumarin derivatives, acyclic nucleoside analogues, antitumor activity evaluation}, journal = {Molecules}, doi = {10.3390/molecules170911010}, volume = {17}, number = {9}, issn = {1420-3049}, title = {Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity}, keyword = {1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine coumarin derivatives, acyclic nucleoside analogues, antitumor activity evaluation} }
@article{article, year = {2012}, pages = {11010-11025}, DOI = {10.3390/molecules170911010}, keywords = {1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine coumarin derivatives, acyclic nucleoside analogues, antitumor activity evaluation}, journal = {Molecules}, doi = {10.3390/molecules170911010}, volume = {17}, number = {9}, issn = {1420-3049}, title = {Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity}, keyword = {1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine coumarin derivatives, acyclic nucleoside analogues, antitumor activity evaluation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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