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Pregled bibliografske jedinice broj: 59257

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.


Sikirić, Predrag; Seiwerth, Sven; Grabarević, Željko; Petek, Marijan; Ručman, Rudolf; Turković, Branko; Rotkvić, Ivo; Jagić, Vjekoslav; Duvnjak, Marko; Miše, Stjepan et al.
The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides. // Life sciences (1973), 54 (1994), 5; PL 63-PL 68 (međunarodna recenzija, pismo, znanstveni)


Naslov
The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

Autori
Sikirić, Predrag ; Seiwerth, Sven ; Grabarević, Željko ; Petek, Marijan ; Ručman, Rudolf ; Turković, Branko ; Rotkvić, Ivo ; Jagić, Vjekoslav ; Duvnjak, Marko ; Miše, Stjepan ; Đačić, Sanja ; Šeparović, Jadranka ; Veljača, Marija ; Sallmani, A. ; Banić, Marko ; Brkić, Tomislav

Izvornik
Life sciences (1973) (0024-3205) 54 (1994), 5; PL 63-PL 68

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
Pentadecapeptide BPC 157

Sažetak
The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptide BPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26-30/was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE