Napredna pretraga

Pregled bibliografske jedinice broj: 591619

Quinone methides: photochemical generation and its application in biomedicine


Basarić, Nikola; Mlinarić-Majerski, Kata; Kralj, Marijeta
Quinone methides: photochemical generation and its application in biomedicine // Current organic chemistry, 18 (2014), 1; 3-18 doi:10.2174/138527281801140121122330 (međunarodna recenzija, članak, znanstveni)


Naslov
Quinone methides: photochemical generation and its application in biomedicine

Autori
Basarić, Nikola ; Mlinarić-Majerski, Kata ; Kralj, Marijeta

Izvornik
Current organic chemistry (1385-2728) 18 (2014), 1; 3-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA alkylating agents ; DNA cross-linking ; excited-state intramolecular proton transfer (ESIPT) ; photo-deammination ; photo-dehydration ; quinone methides

Sažetak
Quinone methides (QMs) are important intermediates in chemistry and biochemistry of phenols that are characterized by wide biological activity. Some classes of anticancer antibiotics exhibit their effect due to methabolic formation of QMs that alkylate DNA. Photochemical reactions provide mild and easy approach to QMs. Photoreactions that give QMs include cleavage of oxa-heterocycles, dehydrohalogenation, dehydration, deammination, excited state intramolecular proton transfer (ESIPT) and tautomerizations of phenols. This critical review (137 references) features different photochemical reactions giving QMs that are applicable in biology and medicine.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
02.05/25

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati