engleski

Corticosteroids provoke acute endothelial injury - An ideal ground for thrombosis in multiple sclerosis

Despite the effect corticosteroids exert on blood clotting and the irrefutable impact of intracranial pressure decreasing shortly after lumbar puncture, a certain number of intracranial thromboses remain unexplained. Corticosteroids are useful in reducing the severity and duration of relapses of multiple sclerosis (MS). Several questions emerge concerning the reasons behind thrombosis occurring so sporadically, not pertaining to any rule, the most important of which regard the location and timing. We developed this hypothesis as an obverse to chronic endothelial injury theory which, only partially explains atherosclerosis development. We followed Virchow’s classical triad of conditions which are believed to be connected to the development of thrombosis. Although corticosteroids affect more than vessel wall injury, component of Virchow’s triad that has been our narrowest interest is exactly vessel wall injury.

acute endothelial injury; perivascular compartments; multiple sclerosis; corticosteroids

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