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Pregled bibliografske jedinice broj: 590714

Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer


Jaganjac, Morana; Čačev, Tamara; Čipak, Ana; Kapitanović, Sanja; Gall-Troselj, Koraljka; Žarković, Neven
Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer // Croatian medical journal, 53 (2012), 4; 304-309 doi:10.3325/cmj.2012.53.304 (međunarodna recenzija, članak, znanstveni)


Naslov
Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer

Autori
Jaganjac, Morana ; Čačev, Tamara ; Čipak, Ana ; Kapitanović, Sanja ; Gall-Troselj, Koraljka ; Žarković, Neven

Izvornik
Croatian medical journal (0353-9504) 53 (2012), 4; 304-309

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Oxidative stress; personalized medicine

Sažetak
Pathophysiological processes associated with disturbances in cell and tissue oxidative homeostasis, are associated with self-catalyzed process of lipid peroxidation. The end products of lipid peroxidation are reactive aldehydes such as 4-hydroxy-2-nonenal (HNE), acting as "second messengers of free radicals." Although reactive aldehydes were first recognized only as cytotoxic, new evidence has come to light, related to their cell growth regulatory functions achieved through cell signaling. The variable appearance of HNE in several organs indicates that its mode of action might be related to an individual cell stress adaptation. The underlying mechanism could be that specific mutations and epigenetic changes on one hand interfere with hormesis on the other. The precise role of oxidative stress and lipid peroxidation in these processes still needs more clarification at molecular level. Finally, an individual approach to each patient, based on the individual cell response to stress, opens a new possibility of integrative medicine in cancer treatment and strongly supports modern concepts of personalized medicine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Sanja Kapitanović, )
098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Koraljka Gall-Trošelj, )
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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