Napredna pretraga

Pregled bibliografske jedinice broj: 590565

PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT


Basarić, Nikola
PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT // 4th Young Investigators Workshop
Beč, Austrija, 2012. (predavanje, nije recenziran, sažetak, znanstveni)


Naslov
PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT

Autori
Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Young Investigators Workshop / - Beč, Austrija, 2012

Skup
4th Young Investigators Workshop

Mjesto i datum
Beč, Austrija, 23-26.08.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Quinone methides; Photodehydration; Photochemistry

Sažetak
Quinone methides (QM) are important intermediates in the chemistry and photochemistry of phenols that have received significant attention in the last 10 years due to their biological activity. Several classes of anticancer drugs base their action on methabolic formation of QMs that alkylate DNA. One of the methods to generate QMs relies on photochemical reaction of dehydration of hydroxy-substituted benzocarbinols. We became interested in photochemical formation of QMs substituted with bulky adamantyl substituents that have longer lifetimes than the corresponding non-substituted analogues, and therefore higher selectivity in the reactions with nucleophiles, rendering them applicable for biological systems.1 Photochemical reactivity of several classes of phenols 1 and 2, 1-3 and naphthols 34 were conducted wherein QMs were characterized by laser flash photolysis. In addition, antiproliferative investigation was carried out on three cancer cell lines in the presence of compounds, with and without exposure to light. We have shown that irradiation of cells treated with adamantyl derivative of 4-hydroxybiphenyl or 2-naphthol induce stronger antiproliferative activity than the nonirradiated samples, in accordance with the transient formation of QMs.3, 4

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
02.05/25
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Kata Majerski, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Nikola Basarić, (250000)