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PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT (CROSBI ID 588878)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Basarić, Nikola PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT // 4th Young Investigators Workshop. Beč, 2012. str. 38-x

Podaci o odgovornosti

Basarić, Nikola

engleski

PHOTOCHEMICAL FORMATION OF QUINONE METHIDES AND INVESTIGATION OF THEIR ANTIPROLIFERATIVE EFFECT

Quinone methides (QM) are important intermediates in the chemistry and photochemistry of phenols that have received significant attention in the last 10 years due to their biological activity. Several classes of anticancer drugs base their action on methabolic formation of QMs that alkylate DNA. One of the methods to generate QMs relies on photochemical reaction of dehydration of hydroxy-substituted benzocarbinols. We became interested in photochemical formation of QMs substituted with bulky adamantyl substituents that have longer lifetimes than the corresponding non-substituted analogues, and therefore higher selectivity in the reactions with nucleophiles, rendering them applicable for biological systems.1 Photochemical reactivity of several classes of phenols 1 and 2, 1-3 and naphthols 34 were conducted wherein QMs were characterized by laser flash photolysis. In addition, antiproliferative investigation was carried out on three cancer cell lines in the presence of compounds, with and without exposure to light. We have shown that irradiation of cells treated with adamantyl derivative of 4-hydroxybiphenyl or 2-naphthol induce stronger antiproliferative activity than the nonirradiated samples, in accordance with the transient formation of QMs.3, 4

Quinone methides; Photodehydration; Photochemistry

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Podaci o prilogu

38-x.

2012.

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objavljeno

Podaci o matičnoj publikaciji

4th Young Investigators Workshop

Beč:

Podaci o skupu

4th Young Investigators Workshop

predavanje

23.08.2012-26.08.2012

Beč, Austrija

Povezanost rada

Kemija