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Interaction of Spermine-Alanine Functionalized Perylene Bisimide Dye Aggregates with ds-DNA/RNA Secondary Structure


Rehm, Thomas H.; Radić Stojković, Marijana; Rehm, Stefanie; Škugor, Marko; Piantanida, Ivo; Würthner, Frank
Interaction of Spermine-Alanine Functionalized Perylene Bisimide Dye Aggregates with ds-DNA/RNA Secondary Structure // Chemical Science, 3 (2012), 12; 3393-3397 doi:10.1039/c2sc20825c (međunarodna recenzija, članak, znanstveni)


Naslov
Interaction of Spermine-Alanine Functionalized Perylene Bisimide Dye Aggregates with ds-DNA/RNA Secondary Structure

Autori
Rehm, Thomas H. ; Radić Stojković, Marijana ; Rehm, Stefanie ; Škugor, Marko ; Piantanida, Ivo ; Würthner, Frank

Izvornik
Chemical Science (2041-6520) 3 (2012), 12; 3393-3397

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Perylene bisimide; aggregates; DNA; RNA; CD spectropolyrimetry

Sažetak
We report for the first time on the interaction of self-assembled PBI dye aggregates with polynucleotides, revealing very high (nM) binding constants and exceptional thermal stabilization of double-stranded (ds)-DNA/RNA. Induced CD profiles of PBI dimer aggregates formed within DNA/RNA grooves show high sensitivity on the steric properties of the binding site, suggesting the applicability of such self-adjusting excitonically coupled PBI dimers for the sensing of the DNA/RNA secondary structure.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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