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Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer (CROSBI ID 185725)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Zec, Ivana ; Kučak, Ivana ; Begčević, Ilijana ; Šimundić, Ana-Maria ; Tišlarić-Medenjak, Dubravka ; Bukovec Megla, Željka ; Vrkić, Nada Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer // Clinical biochemistry, 45 (2012), 15; 1206-1212. doi: 10.1016/j.clinbiochem.2012.05.019

Podaci o odgovornosti

Zec, Ivana ; Kučak, Ivana ; Begčević, Ilijana ; Šimundić, Ana-Maria ; Tišlarić-Medenjak, Dubravka ; Bukovec Megla, Željka ; Vrkić, Nada

engleski

Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer

Objectives were to establish reference intervals for luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), total and free testosterone (T) and sex-hormone binding globulin (SHBG) in prepubertal children and to assess age- and gender-related differences. A total of 948 subjects, 480 girls and 468 boys, between 1 and 11 years of age, were included in this study. All assays were performed on a Roche cobas e 411 immunoassay analyzer. Reference intervals have been evaluated according to the most recent CLSI guidelines. Median values of LH, FSH and T were significantly higher in subgroups ranging from ≥8 to <11 years, for both genders. In girls of that age, reference values of E2 were significantly higher than in younger ones, and in boys of the corresponding age. Established reference intervals are applicable to other laboratories that use the same instrumentation.

reference intervals; reproductive hormones; prepubertal children; Roche analyzer

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Podaci o izdanju

45 (15)

2012.

1206-1212

objavljeno

0009-9120

10.1016/j.clinbiochem.2012.05.019

Povezanost rada

Kliničke medicinske znanosti, Farmacija

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