Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer (CROSBI ID 185725)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zec, Ivana ; Kučak, Ivana ; Begčević, Ilijana ; Šimundić, Ana-Maria ; Tišlarić-Medenjak, Dubravka ; Bukovec Megla, Željka ; Vrkić, Nada
engleski
Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer
Objectives were to establish reference intervals for luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), total and free testosterone (T) and sex-hormone binding globulin (SHBG) in prepubertal children and to assess age- and gender-related differences. A total of 948 subjects, 480 girls and 468 boys, between 1 and 11 years of age, were included in this study. All assays were performed on a Roche cobas e 411 immunoassay analyzer. Reference intervals have been evaluated according to the most recent CLSI guidelines. Median values of LH, FSH and T were significantly higher in subgroups ranging from ≥8 to <11 years, for both genders. In girls of that age, reference values of E2 were significantly higher than in younger ones, and in boys of the corresponding age. Established reference intervals are applicable to other laboratories that use the same instrumentation.
reference intervals; reproductive hormones; prepubertal children; Roche analyzer
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Podaci o izdanju
45 (15)
2012.
1206-1212
objavljeno
0009-9120
10.1016/j.clinbiochem.2012.05.019
Povezanost rada
Kliničke medicinske znanosti, Farmacija