engleski

Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry

ortho- and para-phenylenediamine were desymmetrised and quantitatively transformed into mono- and bis-(thio)ureas or mixed thiourea/ureas through a one-pot mechanochemical click reaction sequence ; mechanochemical desymmetrisation proceeds quantitatively without excess reagents and allows the controlled extension of a molecular structure by combining normally competing reactions.

mechanochemistry; thioureas; one-pot click reaction

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