Platelet serotonin in primary Sjögren's syndrome: Level and relation with disease activity (CROSBI ID 185431)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Šarac, Helena ; Markeljević, Jasenka ; Mokrović, Gordana ; Erdeljić, Viktorija ; Božina, Nada ; Čičin- Šain, Lipa
engleski
Platelet serotonin in primary Sjögren's syndrome: Level and relation with disease activity
Primary Sjögren's syndrome (pSS) is chronic autoimmune disorder of unknown ethiopathogenesis. In line with the concept of neuroimmunohormonal dysregulation in inflammatory rheumatic diseases, the aim of this study was to investigate platelet serotonin level (PSL) in patients with pSS and its relation with the activity and duration of the disease. Significantly lower PSL in pSS patients (N=61) was shown as compared to healthy controls (N=103). No correlation was found between PSL and the actual disease activity assessed by the recently developed EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI). Results suggest involvement of the serotonin system in the pathogenesis of pSS.
platelet serotonin ; Sjögren's syndrome ; ESSDAI
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Podaci o izdanju
251 (1/2)
2012.
87-89
objavljeno
0165-5728
1872-8421
10.1016/j.jneuroim.2012.06.011
Povezanost rada
Biologija, Kliničke medicinske znanosti, Temeljne medicinske znanosti