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Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit


Matanović-Škugor, Maja; Štimac, Vlado; Palej, Ivana; Lugarić, Đurđica; Čipčić Paljetak, Hana; Filić, Darko; Modrić, Marina; Đilović, Ivica; Gembarovski, Dubravka; Mutak, Stjepan et al.
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit // Bioorganic & medicinal chemistry, 18 (2010), 17; 6547-3558 doi:10.1016/j.bmc.2010.06.050 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit

Autori
Matanović-Škugor, Maja ; Štimac, Vlado ; Palej, Ivana ; Lugarić, Đurđica ; Čipčić Paljetak, Hana ; Filić, Darko ; Modrić, Marina ; Đilović, Ivica ; Gembarovski, Dubravka ; Mutak, Stjepan ; Eraković Haber, Vesna ; Holmes, David J. ; Ivezić-Schoenfeldd, Zrinka ; Alihodžić, Sulejman

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 18 (2010), 17; 6547-3558

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Macrolide; quinolone; antibacterial activity; resistance

Sažetak
The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quionolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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