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Pregled bibliografske jedinice broj: 587787

Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II)


Gredičak, Matija; Bregović, Nikola; Carić, Dejana; Jerić, Ivanka
Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II) // Journal of inorganic biochemistry, 116 (2012), 45-52 doi:10.1016/j.jinorgbio.2012.07.014 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 587787 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II)

Autori
Gredičak, Matija ; Bregović, Nikola ; Carić, Dejana ; Jerić, Ivanka

Izvornik
Journal of inorganic biochemistry (0162-0134) 116 (2012); 45-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
copper(II) complexes; peptidomimetics; turn-like conformation; stability constants; enediyne moiety

Sažetak
The importance of turn-like peptide conformation for the copper(II) binding has been revealed by the synthesis of simple amino acid-based tweezers and study of their interaction with copper(II). Amino acids Phe, Leu, Val, Ala and Gly were bridged through their C-terminuses with conformationally constrained motif, cis enediyne moiety ((Z)-octa-4-en-2, 6-diyne-1, 8-diamine). The interaction of prepared diamine ligands with copper(II) was studied by means of potentiometric titrations, UV-visible and EPR spectroscopic and mass spectrometric techniques. All ligands interact efficiently with copper(II) and form complexes of 1:1 stoichiometry differing in the protonation state of the ligand. LCu2+ species were found predominant at pH < 6.5, with log K* ranging from -8.06 to -6.65 while at higher pH deprotonation occurred, giving rise to LH-1Cu+ complexes or LH-2Cu complex for the phenylalanine- related ligand. An additional species, LH-3Cu- were found at pH  9 for the valine- and alanine- related ligands, respectively. Comparing stability of studied complexes with those reported in previous work revealed that ligands effectively emulate properties of copper(II) binding peptides. Based on the results obtained in this work it can be concluded that structural rigidity significantly enhances coordination properties of the ligand, thus conforming importance of the turn-like peptide conformation for the copper(II) binding.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
098-0982933-2936 - Kemijske preobrazbe prirodnih spojeva (Varga-Defterdarović, Lidija, MZOS ) ( POIROT)
119-1191342-2960 - Elektroliti i koordinacijske reakcije u otopini (Tomišić, Vladislav, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Matija Gredičak (autor)

Avatar Url Dejana Carić (autor)

Avatar Url Ivanka Jerić (autor)

Avatar Url Nikola Bregović (autor)

Citiraj ovu publikaciju

Gredičak, Matija; Bregović, Nikola; Carić, Dejana; Jerić, Ivanka
Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II) // Journal of inorganic biochemistry, 116 (2012), 45-52 doi:10.1016/j.jinorgbio.2012.07.014 (međunarodna recenzija, članak, znanstveni)
Gredičak, M., Bregović, N., Carić, D. & Jerić, I. (2012) Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II). Journal of inorganic biochemistry, 116, 45-52 doi:10.1016/j.jinorgbio.2012.07.014.
@article{article, year = {2012}, pages = {45-52}, DOI = {10.1016/j.jinorgbio.2012.07.014}, keywords = {copper(II) complexes, peptidomimetics, turn-like conformation, stability constants, enediyne moiety}, journal = {Journal of inorganic biochemistry}, doi = {10.1016/j.jinorgbio.2012.07.014}, volume = {116}, issn = {0162-0134}, title = {Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II)}, keyword = {copper(II) complexes, peptidomimetics, turn-like conformation, stability constants, enediyne moiety} }
@article{article, year = {2012}, pages = {45-52}, DOI = {10.1016/j.jinorgbio.2012.07.014}, keywords = {copper(II) complexes, peptidomimetics, turn-like conformation, stability constants, enediyne moiety}, journal = {Journal of inorganic biochemistry}, doi = {10.1016/j.jinorgbio.2012.07.014}, volume = {116}, issn = {0162-0134}, title = {Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II)}, keyword = {copper(II) complexes, peptidomimetics, turn-like conformation, stability constants, enediyne moiety} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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