engleski

Activation of lipid metabolism in canine babesiosis caused by Babesia canis

Background: Development of medicine, biochemistry and immunology has provided a more complete insight into factors which take part in the pathogenesis of canine babesiosis. Today it is known that the inflammatory mechanism has a major role in complicated and severe form of disease. Lipid metabolism is of importance in babesiosis within the acute phase response as a part of a complex process regulated by nervous and endocrine system and also because of the fact that the majority of hemoparasites including babesia cannot synthesize their own lipids, so they take them up from host plasma, predominantly from high density lipoproteins fraction. Objective: The aim of this research was to determine if there are changes in lipid metabolism during babesiosis and when they occur during the course of disease. Methods: Research were conduct on 17 healthy and 26 naturally infected dogs. Blood samples were taken on 1st day, (at admission), and on 3rd and 7th day after admission. Biochemical parameters were obtained using an automated biochemical analyzer (Olympus AU 600) according to standard methods with original reagent kits. Biochemical profile included triglycerides, high density lipoproteins, low density lipoproteins and cholesterol. Results: In this research it was established that the cholesterol concentration has significantly increased on day 3 in sick dogs, while the high density lipoproteins concentration had significantly decreased at day 1. There were no major alterations in the triglyceride and low density lipoproteins concentration. Conclusion: This study confirms that lipid metabolism is being activated during babesiosis.

dog ; babesiosis ; triglycerides ; HDL ; LDL ; cholesterol

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