engleski

Post-traumatic changes of insulin like growth factor type 1 and growth hormone in patients with bone fractures and traumatic brain injury

The aim of this study was to analyse if serum changes of growth hormone (GH) and insulin-like growth factor type 1 (IGF-1) are related to the phenomenon of enhanced osteogenesis in patients with bone fracture combined with traumatic brain injury (TBI), which would further suggest their involvement in posttraumatic stress and applicability in promotion of bone fracture healing. GH values were raised during the initial post-traumatic period in all the patients (those with either bone fractures or TBI alone or combined injury associated with the enhanced osteogenesis), declining to normal values afterwards. However, further increase of GH values was noticed only for patients with combined injury overlapping with the time of clinically manifested enhanced osteogenesis. Serum values of IGF-1 were above normal through the entire period analysed (14 weeks) in patients with TBI only, but not if TBI was combined with bone fractures followed by enhanced osteogenesis. For these patients IGF-1 values were raising up gradually during fracture healing period, similar to the patients with bone fractures alone. Thus, different patterns of post-traumatic changes of both GH and IGF-1 in patients with TBI or bone fractures in comparison to patients with combined injury indicate their involvement in post-traumatic stress response and in the phenomenon of enhanced osteogenesis in patients with bone fractures and TBI.

bone fractures; brain; growth hormone; insulin-like growth factor type 1; trauma

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