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Pregled bibliografske jedinice broj: 586238

Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine


Racané, Livio; Kraljević Pavelić, Sandra; Ratkaj, Ivana; Stepanić, Višnja; Pavelić, Krešimir; Tralić-Kulenovića, Vesna; Karminski-Zamola, Grace
Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine // European journal of medicinal chemistry, 55 (2012), 108-116 doi:10.1016/j.ejmech.2012.07.005 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine

Autori
Racané, Livio ; Kraljević Pavelić, Sandra ; Ratkaj, Ivana ; Stepanić, Višnja ; Pavelić, Krešimir ; Tralić-Kulenovića, Vesna ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 55 (2012); 108-116

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Synthesis ; bis-benzothiazolyl substituted pyridines and pyrazine ; amidines ; antiproliferative activity

Sažetak
Novel diamidino substituted conformationally restricted derivatives of bis-benzothiazolyl-pyridines and pyrazine were synthesized and their antiproliferative activity against several human cancer cell lines were determinated. The synthetic approach used for preparation of isomeric amidinobenzotiazolyl disubstituted pyridines 3a-3k and pyrazine 3l was achieved by condenzation reaction of commercially available pyridine and pyrazine dicarboxylic acids with amidino- 2a and 2-imidazolinyl-substituted 2-aminothiophenol 2b in polyphosphoric acid in moderate to good yield. The condenzation reaction was greatly optimized. The targeted compounds were converted in the desired water soluble dihydrochloride salts by reaction of appropriate free base with concd HCl in ethanol or acetic acid. Antiproliferative assays revealed significant differences in antiproliferative activities of diamidino– and diimidazolinyl- derivatives, the latter exerting stronger concentration-dependent antiproliferative effects on tested tumor cell lines and thus being a prominent compound class for further chemical optimization and biological studies. Biological studies on SW620 cell line and BJ fibroblasts perfomed for the diimidazolinyl- derivative 3b revealed oxidative stress as a possible mechanism of antiproliferative action and predicted antineoplastic properties for this class of compounds.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
117-0000000-3283 - Istraživanje novih višenamjenskih bojila i optičkih bjelila (Livio Racane, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-239

Ustanove
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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