engleski

Solvent-free quantitative synthesis of thiourea organocatalysts and anion sensors by click-mechanochemistry

A mechanical treatment of organic reagents by simply grinding them together has reappeared as one of the "green solutions" to environmentally-related issues of the modern organic chemistry industry. Organic mechanosynthesis could therefore replace the conventional synthetic methods allowing for a clean and environmentally-benign route to C-C bond formation as well as to many fullerene-based and heterocyclic systems. In this contribution, mechanochemical methods of neat grinding and liquid-assisted grinding have been applied for the synthesis of known thiourea-based chiral organocatalysts and anion sensors using the click coupling of aromatic and aliphatic diamines with aromatic isothiocyanates. Quantitative reaction yields, combined with solvent-free nature of mechanochemical synthesis provided a simple and clean procedure to fully transform valuable enantiomerically pure reagents into structurally diverse products that could be immediately applied for a designed purpose.

mechanochemistry

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