Hydroxyquinoline based binders: Promising ligands for chelatotherapy? (CROSBI ID 184758)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Budimir, Ana ; Humbert, Nicholas ; Elhabiri, Mourad ; Osinska, Iwona ; Biruš, Mladen ; Albrecht-Gary, Anne-Marie
engleski
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease.
Clioquinol; Alzheimer's disease; Metal ions; Stability constants
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Podaci o izdanju
105 (3)
2011.
490-496
objavljeno
0162-0134
10.1016/j.jinorgbio.2010.08.014,