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Pregled bibliografske jedinice broj: 583176

FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent


Feher Turković, Lana; Pizent, Alica; Dodig, Slavica; Pavlović, Mladen; Pašalić, Daria
FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent // Biochemia Medica, 22 (2012), 2; 217-224 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 583176 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent

Autori
Feher Turković, Lana ; Pizent, Alica ; Dodig, Slavica ; Pavlović, Mladen ; Pašalić, Daria

Izvornik
Biochemia Medica (1330-0962) 22 (2012), 2; 217-224

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
fatty acid-binding proteins (FABPs); FABP2 genetic polymorphism; metabolic syndrome

Sažetak
Metabolic syndrome (MetS) is a multifactorial disorder in which dyslipidemia plays an important role. Fatty acid-binding protein 2 (FABP 2) is responsible for transport of free fatty acids in the intestinal endothelium cells. FABP2-genetic variants might affect plasma lipid concentrations and intracellular lipid transport. The aim of this study was to investigate the association between FABP2 Ala54Thr genetic polymorphism and metabolic syndrome and some biochemical and anthropological parameters in elderly subjects. This cross-sectional study included 140 men and 176 women older than 70 years. Fasting serum concentration of glucose, lipid parameters, total proteins and C-reactive protein were determined by standardized methods. Presence (MetS(+)) or absence (MetS(-)) of MetS was determined according to criteria of the International Diabetes Federation. FABP2 genetic polymorphism Ala54Thr (rs1799883) was genotyped with PCR-RFPL. The genotype frequencies for Ala/Ala, Ala/Thr and Thr/Thr genotype were 60, 36 and 6 in MetS(-), and 131, 70 and 13 in MetS(+), respectively, without statistical significance (P = 0.567). Ala/Ala genotype was a subgroup of non-carriers, while Ala/Thr and Thr/Thr genotypes were Thr54-carriers. Median triglyceride concentration was significantly lower in carriers then in non-carriers for whole MetS(+) group (P = 0.050) ; there were no significant difference between men with MetS (P = 0.144), but there was a difference between women with MetS (P = 0.020). T-test showed that mean HDL cholesterol concentrations in MetS(+) group for Thr54-carriers was significantly higher in whole group (P = 0.001), and for both genders (men P = 0.039 ; women P = 0.004) as compared to non-carriers. FABP2 genetic polymorphism is associated with lower triglyceride and higher HDL-cholesterol concentrations in elderly subjects with MetS. This genetic variation might be a useful marker for understanding dyslipidemia in MetS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
108-1080316-0298 - Molekularna osnova aterogeneze (, )
022-0222411-2407 - PROCJENA RIZIKA POBOLA I SMRTNOSTI U POPULACIJI HRVATSKE: - PROSPEKTIVNA STUDIJA (Pavlović, Mladen, MZOS - )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Feher Turković, Lana; Pizent, Alica; Dodig, Slavica; Pavlović, Mladen; Pašalić, Daria
FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent // Biochemia Medica, 22 (2012), 2; 217-224 (međunarodna recenzija, članak, znanstveni)
Feher Turković, L., Pizent, A., Dodig, S., Pavlović, M. & Pašalić, D. (2012) FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent. Biochemia Medica, 22 (2), 217-224.
@article{article, year = {2012}, pages = {217-224}, keywords = {fatty acid-binding proteins (FABPs), FABP2 genetic polymorphism, metabolic syndrome}, journal = {Biochemia Medica}, volume = {22}, number = {2}, issn = {1330-0962}, title = {FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent}, keyword = {fatty acid-binding proteins (FABPs), FABP2 genetic polymorphism, metabolic syndrome} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE





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