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Pregled bibliografske jedinice broj: 579901

Horizontal gene transfer drives convergent evolution of modular polyketide synthases

Zucko, Jurica; Long, F Paul; Hranueli, Daslav; Cullum, John
Horizontal gene transfer drives convergent evolution of modular polyketide synthases // Journal of industrial microbiology & biotechnology, 39 (2012), 10; 1541-1547 doi:10.1007/s10295-012-1149-2 (međunarodna recenzija, članak, znanstveni)

Horizontal gene transfer drives convergent evolution of modular polyketide synthases

Zucko, Jurica ; Long, F Paul ; Hranueli, Daslav ; Cullum, John

Journal of industrial microbiology & biotechnology (1367-5435) 39 (2012), 10; 1541-1547

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Evolution; Horizontal gene transfer; Gene conversion; Polyketide synthases

Soil bacteria live in a very competitive environment and produce many secondary metabolites ; there appears to be strong selective pressure for evolution of new compounds. Secondary metabolites are the most important source of chemical structures for the pharmaceutical industry and an understanding of the evolutionary process should help in finding novel chemical entities. Modular polyketide synthases are a particularly interesting case for evolutionary studies, because much of the chemical structure can be predicted from DNA sequence. Previous evolutionary studies have concentrated on individual modules or domains and were not able to study the evolution of orthologs. This study overcame this problem by considering complete clusters as "organisms", so that orthologous modules and domains could be identified and used to characterise evolutionary pathways. Seventeen modular polyketide synthase clusters were identified that fell into six classes. Gene conversion within clusters was very common (affecting about 15% of domains) and was detected by discordance in phylogenetic trees. An evolutionary model is proposed in which a single cross over between two different clusters (i.e. horizontal gene transfer) would generate a cluster of very different architecture with radically different chemical products ; subsequent gene conversion and deletions would explore chemical variants. Two probable examples of such recombination were found. This model suggests strategies for detecting horizontal gene transfer in cluster evolution.

Izvorni jezik

Znanstvena područja


Projekt / tema
058-0000000-3475 - Generiranje potencijalnih lijekova u uvjetima in silico (Daslav Hranueli, )

Prehrambeno-biotehnološki fakultet, Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus