Anti-citrullinated antibodies, radiological joint damages and their correlations with disease activity score (DAS28) (CROSBI ID 183607)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Glasnović, Marija ; Bošnjak, Ivica ; Včev, Aleksandar ; Soldo, Ivan ; Glasnović-Horvatić, Elizabeta ; Soldo-Butković, Silva ; Pavela, Jasna ; Mićunović, Nikola
engleski
Anti-citrullinated antibodies, radiological joint damages and their correlations with disease activity score (DAS28)
Determination of anti-citrullinated peptides (anti-CCP) specificity as a predictor of joint erosive changes, correlation between their serum level and radiological damages as well as disease activity score (DAS28). A trial has been conducted on a 211 patient sample fulfilling ACR criteria for rheumatoid arthritis (RA). There was assigned anti-CCP serum level, disease activity score by the formula for DAS28(3)-CRP and assessed radiological changes degree after Steinbrocker score. In 132 patient (62.559%) the serum anti-CCP concentration was positive for RA. Specificity of the test was 100% and sensitivity 65% (Z = 0.731, p = 0.465). There is a medium intensity correlation between variables representing anti-CCP and Steinbrocker score. Pearson's coefficient was 0.479 and Spearman's rank correlation coefficient was 0.614, i.e. statistically significant (p = 0.000). There is no statistically significant correlation between variables representing anti-CCP and DAS28(3)-CRP Anti-CCP are good RA predictor and their concentration correlate with radiological damages degree.
anti-citrullinated antibodies; rheumatoid arthritis; disease activity score; radiological damages
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano