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Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism


Bordukalo-Nikšić, Tatjana; Štefulj, Jasminka; Matošić, Ana; Mokrović, Gordana; Čičin-Šain, Lipa
Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism // Psychiatry research, 200 (2012), 2/3; 1041-1043 doi:10.1016/j.psychres.2012.04.031 (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism

Autori
Bordukalo-Nikšić, Tatjana ; Štefulj, Jasminka ; Matošić, Ana ; Mokrović, Gordana ; Čičin-Šain, Lipa

Izvornik
Psychiatry research (0165-1781) 200 (2012), 2/3; 1041-1043

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Serotonin transporter; monoamine-oxidase; alcoholism subtypes

Sažetak
Combinatory effect of polymorphisms in serotonin transporter and monoamine oxidase-A genes on the etiopathogenesis of alcoholism was investigated in sample of 714 individuals. Increased frequency of subjects having three "suspected" genotypes (5-HTTLPR-LL, STin2-1010, MAO-A 3-repeat allele) was found among type-2 alcoholic patients (P=0.0189). Results highlight serotonergic/genetic contribution to early-onset alcoholism.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )
098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Lipa Čičin-Šain, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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