Ferrocenyl-Labeled Sugar Amino Acids: Conformation and Properties (CROSBI ID 183410)
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Podaci o odgovornosti
Förster, Christoph ; Kovačević, Monika ; Barišić, Lidija ; Rapić, Vladimir ; Heinze, Katja
engleski
Ferrocenyl-Labeled Sugar Amino Acids: Conformation and Properties
Novel organometallic sugar amino acid conjugates 1–5 have been prepared by amide coupling of O-protected N-acetylmuramic acid and iso-muramic acid (2-[3-amino-2, 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoic acid) with 1-aminoferrocene, 1-aminoferrocene-1′-carboxylic acid (H-Fca-OH), or 1, 1′-diaminoferrocene, respectively. The influence of the ferrocenyl moiety and presence of additional remote potential hydrogen atom acceptors and donors at the ferrocenyl core on the conformation and lipophilicity is investigated by TLC, IR, NMR, and CD spectroscopic methods augmented by density functional calculations. Furthermore, the redox potential of the ferrocene/ferrocenium couple is tuned by the electron-withdrawing and -donating nature of the substituents at the ferrocenyl label.
conformational analysis; hydrogen bonds; metallocenes; redox chemistry; sugar amino acids
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