Surface Modified Liposomes by Mannosylated Conjugates Anchored via the Adamantyl Moiety in the Lipid Bilayer (CROSBI ID 183321)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Štimac, Adela ; Šegota, Suzana ; Dutour Sikirić, Maja ; Ribić, Rosana ; Frkanec, Leo ; Svetličić, Vesna ; Tomić, Srđanka ; Vranešić, Branka ; Frkanec, Ruža
engleski
Surface Modified Liposomes by Mannosylated Conjugates Anchored via the Adamantyl Moiety in the Lipid Bilayer
The aim of the present study was to encapsulate mannosylated 1-aminoadamantane and mannosylated adamantyltripeptides, namely [(2R)-N-(adamant-1- yl)-3-(a, b-D-mannopyranosyloxy)-2- methylpropanamide and (2R)-N-[3-(α-D- mannopyranosyloxy)-2-methylpropanoyl]-D, L- (adamant-2-yl)glycyl-L-alanyl-D-isoglutamine] in liposomes. The characterization of liposomes, size and surface morphology was performed using dynamic light scattering (DLS) and atomic force microscopy (AFM). The results have revealed that the encapsulation of examined compounds changes the size and surface of liposomes. After the Concanavalin A (ConA) was added to the liposome preparation, increase in liposome size and their aggregation has been observed. The enlargement of liposomes was ascribed to the specific binding of the ConA to the mannose present on the surface of the prepared liposomes. Thus, it has been shown that the adamantyl moiety from mannosylated 1- aminoadamantane and mannosylated adamantyltripeptides can be used as an anchor in the lipid bilayer for carbohydrate moiety exposed on the liposome surface.
adamantane ; mannose ; liposome targeting ; AFM ; DLS
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Podaci o izdanju
1818 (9)
2012.
2252-2259
objavljeno
0005-2736
1879-2642
10.1016/j.bbamem.2012.04.002
Povezanost rada
Biotehnologija, Kemija, Temeljne medicinske znanosti