engleski

Effects of models with finite loci, selekction, dominance, opistasis and linkage on inbreeding coefficients based on pedigree and genotypic information

Considering the effects of selection, epistasis and linkage, a stochastic computer simulation was performed to study how well inbreeding coefficients calculated from pedigree and genotypic frequencies correspond to the inbreeding coefficient that is defined as the proportion of autozygous loci in the modeled genome (i.e. the level of autozygosity). When random mating was practiced as a selection strategy, expectations of all three inbreeding coefficients corresponded closely. When selection was applied, neither the inbreeding coefficient from pedigree nor from the genotypic frequencies corresponded to the average autozygosity in the modeled genome. Bias was present in both directions, thus leading to overestimation or underestimation depending on the genetic model and on the initial gene frequency. Although linkage did not influence the sign of the observed bias, it did enforce the effects of selection, thus increasing the magnitude of the bias. Results presented show when and what kind of caution has to be taken, especially for traits controlled by a small number of loci, when conclusions are based on the inbreeding coefficients estimated from pedigree or decrease in heterozygosity.

inbreeding coefficient; pedigree;

nije evidentirano