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Pregled bibliografske jedinice broj: 574253

Positive reproductive family history for spontaneous abortion : predictor for recurrent miscarriage in young couples


Mišković, Silvana; Čulić, Vida; Konjevoda, Paško; Pavelić, Jasminka
Positive reproductive family history for spontaneous abortion : predictor for recurrent miscarriage in young couples // European journal of obstetrics, gynecology, and reproductive biology, 161 (2012), 2; 182-186 doi:10.1016/j.ejogrb.2011.12.027 (međunarodna recenzija, članak, znanstveni)


Naslov
Positive reproductive family history for spontaneous abortion : predictor for recurrent miscarriage in young couples

Autori
Mišković, Silvana ; Čulić, Vida ; Konjevoda, Paško ; Pavelić, Jasminka

Izvornik
European journal of obstetrics, gynecology, and reproductive biology (0301-2115) 161 (2012), 2; 182-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Recurrent spontaneous abortion ; family history

Sažetak
The etiology of recurrent spontaneous abortions (RSA) (in chromosomally normal parents) is still unexplained. Currently, it is still unclear whether or not some factors (like spontaneous abortions, SA) which occur among extended family members can create a predisposition that may end with a terminated pregnancy. Therefore, this study comprises two parts: a) the epidemiological part, to evaluate the relationship between RSA in 567 couples and the frequency of SA among their first (I), second II) and third (III) generation relatives, and b) the genetic part, presenting whether parental and fetal chromosomal status may predispose the occurrence of RSA. Study design Couples (567) having one or more SA were analyzed in this retrospective case-control study. The family reproductive history data was collected from their medical charts. Results The total number of SA found in 567 couples was 1174. The largest number of abortions occurred between the 8th and 10th week of gestation. The majority of spouses had normal karyotypes (88.5% and 91%). Out of the remaining spouses, 65% (females) and 76% (males) expressed constitutional chromosomal variation, mostly the pericentric inversion of chromosome 9. Cytogenetic analysis performed on aborted material samples showed some type of change in 40% of cases. The family reproductive history data indicated that the number of SA among the couples’ I, II and III generation relatives happened with a frequency of two to three times higher than that of the general population (55.5, 47.6 and 32.6% for female relatives, and 45.8, 44.1 and 15.1% for male I, II and III generation relatives). Conclusion Positive reproductive family history for SA might be the causal factor for RSA and can also predetermine women that are of greater susceptibility to preterm pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Jasminka Pavelić, )
098-2464-2524

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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