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Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA


Dukši, Marko; Baretić, Domagoj; Piantanida, Ivo
Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA // Acta chimica Slovenica, 59 (2012), 3; 464-472 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA

Autori
Dukši, Marko ; Baretić, Domagoj ; Piantanida, Ivo

Izvornik
Acta chimica Slovenica (1318-0207) 59 (2012), 3; 464-472

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Phenanthridine-nucleobase conjugate; DNA; CD; fluorescence

Sažetak
Series of novel peptide-bridged phenanthridine- nucleobase conjugates were prepared by solid phase peptide synthesis, which allowed easy and fast tuning of structure properties. Compounds were fully characterized in aqueous medium, pointing out to intramolecularly stacked structures. The stacked phenanthridine-thymine-phenanthridine system revealed characteristic excimeric fluorescence band and very specific CD spectrum. Studied compounds interact with double stranded DNA by intercalation, whereby binding is to minor extent influenced by attached thymine and amino- acid sequence of the peptide backbone.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Memorial Issue : Celebrating the 70th birthday of Professor Dr. Gorazd Vesnaver.



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Ivo Piantanida, (202026)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus