engleski

Myoepithelial Carcinoma of the Parotid Gland

Rare malignant tumor of the salivary gland, a myoepithelial carcinoma, arose de novo in the right parotid gland. The initial tumour was composed predominantly of myoepithelial cells with cellular pleomorphism. Subsequently the tumour recurred three times, with infiltration of the bones of the cranial base. Histological examination showed sarcomatoid neoplasm composed of malignant spindle cells with high mitotic rate and perineural invasion. There was no involvement of cervical lymph node. Immunohistochemistry demonstrated myoepithelial differentiation: tumour cells are positively stained with vimentin, alpha smooth muscle actin and S-100 protein antibodies, and focal positively was noticed with cytokeratin (AE1/AE3) antibody. Large number of tumors cell nuclei was reactive with the monoclonal anti-p63 antibody, clon 4A4. Myoepithelial carcinomas exibit a wide spectrum of morphological heterogeneity and for that reason could be confused with many tumors. Cytoarchitectural patterns and immunohistochemical profile is crucial for identification. These tumors are malignant neoplasms with diverse clinical outcomes, sometimes very aggressive.

myoepithelial carcinoma ; malignant myoepithelioma ; parotid gland ; immunohystochemistry ; p63 protein

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