The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity (CROSBI ID 181737)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Stanietsky, Noa ; Šimić, Hrvoje ; Arapović, Jurica ; Toporik, Amir ; Levy, Ofer ; Novik, Amit ; Levinec, Zurit ; Beimanc, Meirav ; Dassac, Liat ; Achdout, Hagit ; Stern-Ginossar, Noam ; Tsukermana, Pinhas ; Jonjic, Stipan ; Mandelboim, Ofer
engleski
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM. Finally, we show that TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytoxicity thus providing an “alternative self” mechanism for MHC class I inhibition.
NK cels ; TIGIT ; PVR ; Nectin-2
Israel–Croatia Research Grant
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Podaci o izdanju
106 (42)
2009.
17858-17863
objavljeno
0027-8424
10.1073/pnas.0903474106
Povezanost rada
Temeljne medicinske znanosti