engleski

The relationships between serum anti-Müllerian hormone (AMH) level and the clinical and biochemical characteristics of women with polycystic ovaries

Background. AMH has been the focus of interest due to its potential clinical utility as a marker of ovarian reserve and dysfunction. The objective of the study was to investigate relationships between AMH and biochemical and clinical characteristics of woman with PCOS and compare them with those of women with polycystic ovarian morphology alone (PCO group) and those of women with normal ovaries (control group). Methods. Transvaginal ultrasound assessment, anthropometric measurements and routine laboratory methods in the diagnosis of PCOS were used. Results. A strong correlation was found between antral follicle count (AFC) and serum AMH levels in PCOS (N=67 ; r=0.59), PCO (N=29 ; r=0.64) and the controls (N=108 ; r =0.64).This was the only significant correlation observed in the PCO group. There were significant differences in serum AMH concentration and AFC among the groups. In PCOS women, AMH was also strongly correlated to LH (r=0.35) and menstrual cycle length (r=0.47). AMH levels were found to be in strong inverse correlation with age only in the control group (r=-0.398), whereas no relationship was observed between AMH and BMI, hyperandrogenism, estradiol in any of the groups. Conclusion. Women with PCO alone have distinctive properties compared to controls and women with PCOS diagnosed by the Rotterdam criteria. The high AMH level due to intrinsic dysregulation of granulosa cells might be involved in impaired folliculogenesis in PCOS.

PCOS; AMH; AFC; PCO alone

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