Prognostic factors in carcinoma of the larynx : relevance of DNA ploidy, S-fractions and localization of the tumour (CROSBI ID 181628)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Đanić, Davorin ; Miličić, Damir ; Prgomet, Drago ; Leović, Dinko
engleski
Prognostic factors in carcinoma of the larynx : relevance of DNA ploidy, S-fractions and localization of the tumour
The influence of the cell cycle profile and the site of the primary tumour on the overall survival were examined in 36 patients with squamous cell carcinoma of the larynx. DNA ploidy (p = 0.0091), the overall proliferative activity (p = 0.0001), the overall proliferative activity of diploid tumour cells (p = 0.0017) and primary tumour site (p = 0.0008) were found to be significant single prognostic factors of the overall survival. Multivariate analysis showed that only the overall proliferative activity was prognostically significant (p = 0.013). The results of the study show that the supraglottic site of the tumours correlates significantly with DNA ploidy (p = 0.0334) and the overall proliferative activity of tumour cells (p = 0.0159), whereas the correlation with proliferative activity of diploid tumour cells (p = 0.1416) has not been confirmed by this study. Glottic tumours showed a prognostically significant correlation with the overall proliferative activity (p = 0.0037) and proliferative activity of diploid tumour (p = 0.0054). Such a prognostic correlation was not found for DNA ploidy (p = 0.6542).
larynx; carcinoma; squamous cell; DNA; neoplasm; prognosis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
113 (6)
1999.
538-541
objavljeno
0022-2151
10.1017/S0022215100144433
Povezanost rada
Kliničke medicinske znanosti