Absence of association between genetic polymorphisms in CRFR1 and PTSD (CROSBI ID 584172)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ćurić, Goran ; Pavlinić, Dinko ; Wagner, Jasenka ; Đurković, Marta ; Braš, Marijana ; Lauc, Gordan
engleski
Absence of association between genetic polymorphisms in CRFR1 and PTSD
One of the main mechanisms in the activation of the hypothalamo– pituitary–adrenocortical (HPA) axis is the release of corticotropin releasing hormone hormone (CRH) from the hypothalamus and it’s binding to the corticotropin releasing hormone receptor (CRHR1) in the pituitary gland. Recently it was reported that two haplotype tagging SNPs (htSNP) in CRHR1 are associated with patterns of human alcohol drinking and could potentially contribute to the development of alcohol dependence. Aiming to see whether same genetic variations are associated with potential predisposition for the development of post- traumatic stress disorder (PTSD) we have investigated association of these two haplotypes of CRHR1 and PTSD. DNA was isolated from blood of 200 patients with diagnosed PTSD and 200 matching control individuals. TaqMan Pre- designed SNP genotyping assays were used to genotype two htSNPs (rs242939 corresponding to T to C exchange at position 44371356 and rs1876830 corresponding to C to T exchange at position 44386772 of Chromosome 17). Contrary to the situation observed in alcoholism, we were not able to find any association of CRFR1 genotype with PTSD since frequencies of all alleles were nearly the same in both studied populations. Interestingly, the observed frequency of the major allele at rs242939 corresponded to the frequency reported to correlate with low alcohol consumption, while the observed frequency of the major allele at rs1876830 was between the reported frequencies for low and high alcohol consumers.
CRHR1; PTSD; genetic polymorphism
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
127-127.
2007.
objavljeno
Podaci o matičnoj publikaciji
0031-5362
Podaci o skupu
5. Hrvatski kongres farmakologije i 2. kongres Hrvatskog društva fiziologa
poster
19.02.2007-22.02.2007
Osijek, Hrvatska
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija