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Influence of Mannosylation on Immunostimulating Activity of Adamant-1-yl Tripeptide


Ribić, Rosana; Habjanec, Lidija; Frkanec, Ruža; Vranešić, Branka; Tomić, Srđanka
Influence of Mannosylation on Immunostimulating Activity of Adamant-1-yl Tripeptide // Chemistry & biodiversity, 9 (2012), 7; 1373-1381 doi:10.1002/cbdv.201200008 (međunarodna recenzija, članak, znanstveni)


Naslov
Influence of Mannosylation on Immunostimulating Activity of Adamant-1-yl Tripeptide

Autori
Ribić, Rosana ; Habjanec, Lidija ; Frkanec, Ruža ; Vranešić, Branka ; Tomić, Srđanka

Izvornik
Chemistry & biodiversity (1612-1872) 9 (2012), 7; 1373-1381

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mannose; adamant-1-yl tripeptide; immunostimulating activity; peptidoglycan monomer

Sažetak
The aim of this work was to prepare the mannosylated derivative of adamant-1-yl tripeptide (D-(Ad-1-yl)Gly-L-Ala-D-isoGln) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Mannosylated adamant-1-yl tripeptide (Man-OCH2CH(CH3)CO-D-(Ad- 1-yl)Gly-L-Ala-D-isoGln) is non-pyrogenic, water- soluble and non-toxic compound. Adjuvant activity of mannosylated adamantyltripeptide was tested in the mouse model using ovalbumin as an antigen and in comparison to the parent tripeptide and peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D- MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala), a well known effective adjuvant. The mannosylation of adamantyltripeptide caused the amplification of its immunostimulating activity in such a way that it was comparable to that of PGM.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
021-0212432-2431 - Nove formulacije antigena i imunostimulatora - utjecaj na imunoreakciju (Ruža Frkanec, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Imunološki zavod d.d.,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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