Synthesis of new steroid-beta-lactam hybrids via palladium-catalyzed aminocarbonylation (CROSBI ID 181031)
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Podaci o odgovornosti
Balogh, Janos ; Skoda-Foldes, Rita ; Vazdar, Katarina ; Habuš, Ivan
engleski
Synthesis of new steroid-beta-lactam hybrids via palladium-catalyzed aminocarbonylation
Steroid-beta-lactam and steroid-beta-lactam-ferrocene conjugates were synthesized via palladium-catalyzed carbonylation of steroidal 17-iodo-16-enes in the presence of 3-amino-azetidin-2-ones. beta-Lactam derivatives have been used for the first time as nucleophyles in the aminocarbonylation reaction. The products were obtained in good yields and were characterized by 1H- and 13C-NMR, IR and HRMS.
beta-lactams ; hybrids ; aminocarbonylation ; palladium ; alkenyl iodides
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Podaci o izdanju
703
2012.
51-55
objavljeno
0022-328X
1872-8561
10.1016/j.jorganchem.2011.12.033