Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. (CROSBI ID 583918)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Rojnic Kuzman, Martina ; Medved, Vesna ; Terzić, Janoš ; Božina, Nada ; Krainc, Dimitri
engleski
Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia.
The aim of this study was to analyze gene expression in blood of patients with newly-diagnosed schizophrenia during their first psychotic episode and subsequent remission. Whole blood samples were obtained from 32 untreated patients presenting with their first psychotic episode suggestive of schizophrenia and 32 age- and gender-matched controls. In summary, we identified changes of gene expression from peripheral blood which might help discriminate patients with schizophrenia from controls. While these results are promising, especially for DAAM2 whose polymorphic variants have been found significantly associated with schizophrenia, it will be important to analyze larger cohorts of patients in order to firmly establish changes in gene expression as blood markers of schizophrenia.
genetic expression; blood; biomarkers; schizophrenia; drug naive
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Podaci o prilogu
2008.
objavljeno
Podaci o matičnoj publikaciji
Schizophrenia Research
Podaci o skupu
World congress of psychiatric Genetics
predavanje
11.10.2008-15.10.2008
Osaka, Japan