Influence of Evolutionary Forces and Demographic Processes on the Genetic Structure of Three Croatian Populations - A Maternal Perspective (CROSBI ID 180830)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Šarac, Jelena ; Šarić, Tena ; Jeran, Nina ; Havaš Auguštin, Dubravka ; Metspalu, Ene ; Vekarić, Nenad ; Missoni, Saša ; Villems, Richard ; Rudan, Pavao
engleski
Influence of Evolutionary Forces and Demographic Processes on the Genetic Structure of Three Croatian Populations - A Maternal Perspective
Many Croatian islands are examples of genetic isolates, with low level of heterozygosity and high level of inbreeding, due to practice of endogamy. Our aim was to study the genetic structure of two insular and one mainland population through high-resolution phylogenetic analysis of mitochondrial DNA (mtDNA). MtDNA polymorphisms were explored in 300 unrelated individuals from Mljet, Lastovo and coastal city of Dubrovnik, based on SNP polymorphisms. All mtDNA haplogroups found in the sample were of typical European origin. However, the frequency distribution of their subclades differed significantly from other Croatian and European populations. MtDNA haplotype analysis revealed only two possible founder lineages on Mljet and six on Lastovo, accounting for almost half of the sample on both islands. Island of Mljet also has the lowest reported gene and nucleotide diversity among Croatian isolates and Island of Lastovo a new sublineage of a usual quite rare U1b clade. Our results can be explained by the effect evolutionary forces have on the genetic structure, which is in line with the specific demographic histories of the islands. Additional research value of these two island isolates is also the appearance of certain Mendelian disorders, highlighting their importance in epidemiological studies.
island isolates; mainland; mtDNA; evolutionary forces; demography
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Podaci o izdanju
Povezanost rada
Biologija