engleski

Aspects for Genetic Predisposition - Qualitative Dermatoglyphic Analysis in Carcinomas

Dermatoglyphic traits are well suited for genetic studies because they are polygenetically determined and almost totally established and differentiated by the fourth fetal month, making them almost environmentally stable characters. While there seems to be general agreement that genetic factors play some role in the ethiopathogenesis of carcinoma, many important questions remain unresolved. The purpose of this investigation is to find out if differences between healthy controls and patients suffering of different types of carcinoma exist in qualitative dermatoglyphic with the aim of proving genetic predispositon of the carcinomas. Qualitative dermatoglyphic traits (whorls, loops and arches) on fingers and palms are studied in four different types of bronchopulmonary carcinoma in males and females and compared with healthy controls. Relative frequencies of whorls and loops on fingers differ in carcinoma planocellulare in males and in females. Hiernaux Dg biological distance in males show three separate clusters - first with carcinoma planocellulare, second with carcinoma microcellulare and third with adenocarcinoma, carcinoma macrocellulare and healthy controls. In females only breast carcinoma join in the same cluster with healthy controls, while all other carcinomas create a separate cluster. The largest distance is shown by adenocarinoma in females. The most common bronchopulmonary carcinoma - planocellulare differ in frequencies of patterns on fingers and palms in males and specially in females. Therefore, the endogenic factors are suspected to have important role in appearance of carcinoma planocellulare, as well as in most of other types of carcinoma.

anthropology; population genetics; dermatoglyphic analysis; bronchopulmonary carcinomas

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