engleski

Functional single nucleotide polymorphisms in promoter region of matrix metalloproteinase -1, -2, -3 and -9 as risk factors for recurrent spontaneous abortion

Matrix metalloproteinases (MMP) regulate various processes during human pregnancy, including decidualization, maintenance of corpus lutem, blastocyst implantation and placentation. The aim of this study was to investigate the association of functional promoter polymorphisms in MMP genes with idiopathic recurrent spontaneous abortion (iRSA). 149 couples with iRSA and 149 control couples with at least one live birth and no history of pregnancy loss were included. Polymerase chain reaction and restriction fragment lenght polymorphism analyses were performed to identify the MMP1 -1607 1G/2G, MMP2 -735C/T, MMP2 -1306C/T, MMP3 -1612 5A/6A, and MMP-9 -1562C/T genotypes. Our results show that the functional promoter polymorphisms, haplotype and genotype combinations of MMP-1, -2, -3- and -9 could be a genetic determinant for the risk of RSA.

intercellular matrix; pregnancy

nije evidentirano